Research workbench
F-box protein form 2
Analyse F-box protein form 2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6BRP
- Type
- protein
- Length
- 1,499 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- F-BOX/LRR-repeat MAX2 homolog; SKP1-like protein 1A
- UniProt
- Q5VMP0, Q39255
- Pockets
- 19 · best druggability 0.63
Structure
x-ray diffraction · 4 distinct chains · 37% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | F-BOX/LRR-repeat MAX2 homolog | protein | 620 | 33% helix, 19% strand | Q5VMP0 |
| A | SKP1-like protein 1A | protein | 127 | 55% helix, 10% strand | Q39255 |
| D | F-BOX/LRR-repeat MAX2 homolog | protein | 615 | 34% helix, 19% strand | Q5VMP0 |
| C | SKP1-like protein 1A | protein | 137 | 58% helix, 9% strand | Q39255 |
Pockets
19 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 88 | 0.63 | 0.90 | 20 | empty |
| 2 | 410 | 0.62 | 0.77 | 61 | empty |
| 3 | 53 | 0.62 | 0.93 | 15 | empty |
| 4 | 79 | 0.52 | 0.85 | 22 | empty |
| 5 | 160 | 0.51 | 0.78 | 21 | empty |
Interfaces
3 interfaces between chains.
- B–A · 2088 Ų buried · 28 hydrogen bonds · protein-protein
- D–C · 2078 Ų buried · 29 hydrogen bonds · protein-protein
- B–D · 842 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 6BRP · F-box protein form 2 · the same entry in another collection · chain C against C, TM-score 1.00
- Q5VMP0 · AlphaFold monomer V2.0 prediction for F-BOX/LRR-repeat MAX2 homolog (Q5VMP0) · a predicted model of the same protein · chain B against A, TM-score 1.00
- Q39255 · AlphaFold monomer V2.0 prediction for SKP1-like protein 1A (Q39255) · a predicted model of the same protein · chain C against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5VMP0
- Every structure of UniProt Q39255
- Elsewhere: RCSB PDB 6BRP · PDBe 6BRP · UniProt Q5VMP0 · UniProt Q39255
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