Research workbench
Cryo-EM structure of ENAC
Analyse Cryo-EM structure of ENAC in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6BQN
- Type
- protein
- Length
- 1,815 residues
- Chains
- 7
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SCNN1A; SCNN1B; Egfp-SCNN1G chimera; 7B1 Fab; 10D4 Fab
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 7 distinct chains · 22% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SCNN1A | protein | 439 | 26% helix, 20% strand | — |
| B | SCNN1B | protein | 479 | 30% helix, 23% strand | — |
| C | Egfp-SCNN1G chimera | protein | 443 | 30% helix, 22% strand | — |
| D | 7B1 Fab | protein | 106 | 0% helix, 42% strand | — |
| E | 7B1 Fab | protein | 121 | 5% helix, 41% strand | — |
| F | 10D4 Fab | protein | 115 | 0% helix, 36% strand | — |
| G | 10D4 Fab | protein | 112 | 3% helix, 21% strand | — |
Pockets
20 pockets found on a 1 Å grid, 17 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1138 | 0.86 | 0.87 | 99 | empty |
| 2 | 428 | 0.86 | 0.93 | 58 | empty |
| 3 | 521 | 0.85 | 0.91 | 63 | empty |
| 4 | 436 | 0.81 | 0.89 | 46 | empty |
| 5 | 1018 | 0.81 | 0.82 | 114 | empty |
Interfaces
9 interfaces between chains.
- A–B · 3239 Ų buried · 39 hydrogen bonds · protein-protein
- B–C · 3055 Ų buried · 24 hydrogen bonds · protein-protein
- A–C · 2565 Ų buried · 27 hydrogen bonds · protein-protein
- B–F · 442 Ų buried · 1 hydrogen bond · protein-protein
- A–E · 440 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 25 disulfide (disulfide).
Compared structures
- 6BQN · Cryo-EM structure of ENaC · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6BQN · PDBe 6BQN
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.