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Structure of two-domain translational regulator YIH1 reveals a possible mechanism of action

Analyse Structure of two-domain translational regulator YIH1 reveals a possible… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6BQI
Type: protein
Length: 258 residues
Chains: 1
Method: solution nmr; solution scattering
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein impact homolog
UniProt: P25637
Pockets: 5 · best druggability 0.75

Structure

solution nmr; solution scattering · 1 distinct chain · 37% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein impact homolog	protein	258	37% helix, 20% strand	P25637

Pockets

5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	156	0.75	0.91	30	empty
2	324	0.70	0.83	37	empty
3	238	0.60	0.80	29	empty
4	207	0.54	0.77	24	empty
5	64	0.30	0.74	13	empty

Compared structures

6BQI · Structure of two-domain translational regulator Yih1 reveals a possible mechanism of… · the same entry in another collection · chain A against A, TM-score 1.00
P25637 · AlphaFold monomer V2.0 prediction for protein impact homolog (P25637) · a predicted model of the same protein · chain A against A, TM-score 0.42

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P25637
Elsewhere: RCSB PDB 6BQI · PDBe 6BQI · UniProt P25637

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