Research workbench
Plasmodium vivax invasion blocking monoclonal antibody 10B12
Analyse Plasmodium vivax invasion blocking monoclonal antibody 10B12 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6BPD
- Type
- protein
- Length
- 397 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Monoclonal antibody 10B12 Fab heavy chain; Monoclonal antibody 10B12 Fab light chain
- Pockets
- 3 · best druggability 0.49
Structure
x-ray diffraction · 2 distinct chains · 5% helix, 54% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Monoclonal antibody 10B12 Fab heavy chain | protein | 187 | 5% helix, 57% strand | — |
| B | Monoclonal antibody 10B12 Fab light chain | protein | 210 | 4% helix, 51% strand | — |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 264 | 0.49 | 0.73 | 37 | empty |
| 2 | 176 | 0.47 | 0.75 | 23 | empty |
| 3 | 54 | 0.29 | 0.75 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1525 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6BPD · Plasmodium vivax invasion blocking monoclonal antibody 10B12 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6BPD · PDBe 6BPD
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