Research workbench
Open state structure of the full-length TRPV2 cation channel with a resolved pore turret domain
Analyse Open state structure of the full-length TRPV2 cation channel with a resolved… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6BO4
- Type
- protein
- Length
- 2,500 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transient receptor potential cation channel subfamily V member 2
- UniProt
- Q9WUD2
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 1 distinct chain · 52% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D, B, C | Transient receptor potential cation channel subfamily V member 2 | protein | 625 | 52% helix, 3% strand | Q9WUD2 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1029 | 0.85 | 0.86 | 104 | empty |
| 2 | 1000 | 0.85 | 0.85 | 95 | empty |
| 3 | 1020 | 0.85 | 0.85 | 105 | empty |
| 4 | 1118 | 0.83 | 0.84 | 90 | empty |
| 5 | 1111 | 0.83 | 0.83 | 105 | empty |
Interfaces
4 interfaces between chains.
- A–B · 2155 Ų buried · 2 hydrogen bonds · protein-protein
- D–C · 2122 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 2098 Ų buried · 2 hydrogen bonds · protein-protein
- A–D · 2049 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 6BO4 · Open state structure of the full-length TRPV2 cation channel with a resolved pore turret… · the same entry in another collection · chain D against D, TM-score 1.00
- Q9WUD2 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain A against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9WUD2
- Elsewhere: RCSB PDB 6BO4 · PDBe 6BO4 · UniProt Q9WUD2
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