Research workbench
Cirv P19 mutant T111S in complex with siRNA
Analyse Cirv P19 mutant T111S in complex with siRNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6BJH
- Type
- protein + RNA
- Length
- 329 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA silencing suppressor P19; RNA (5'- R(P*UP*CP*GP*AP*AP*GP*UP*AP*UP*UP*CP*CP*GP*CP*GP*UP…
- UniProt
- Q66104
- Pockets
- 4 · best druggability 0.73
Structure
x-ray diffraction · 4 distinct chains · 36% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA silencing suppressor P19 | protein | 143 | 30% helix, 22% strand | Q66104 |
| B | RNA silencing suppressor P19 | protein | 144 | 41% helix, 22% strand | Q66104 |
| C | RNA (5'- R(P*UP*CP*GP*AP*AP*GP*UP*AP*UP*UP*CP*CP*GP*CP*GP*UP*AP*CP*GP*UP*U)- 3') | rna | 21 | — | — |
| D | RNA (5'- R(P*CP*GP*UP*AP*CP*GP*CP*GP*GP*AP*AP*UP*AP*CP*UP*UP*CP*GP*AP*UP*U)- 3') | rna | 21 | — | — |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 883 | 0.73 | 0.78 | 57 | empty |
| 2 | 815 | 0.70 | 0.76 | 54 | empty |
| 3 | 256 | 0.61 | 0.81 | 41 | empty |
| 4 | 164 | 0.47 | 0.77 | 28 | empty |
Interfaces
6 interfaces between chains.
- C–D · 910 Ų buried · 94 hydrogen bonds · nucleic-nucleic
- A–B · 842 Ų buried · 12 hydrogen bonds · protein-protein
- A–D · 538 Ų buried · 10 hydrogen bonds · protein-nucleic
- B–C · 534 Ų buried · 12 hydrogen bonds · protein-nucleic
- A–C · 513 Ų buried · 6 hydrogen bonds · protein-nucleic
Compared structures
- 6BJH · CIRV p19 mutant T111S in complex with siRNA · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q66104
- Elsewhere: RCSB PDB 6BJH · PDBe 6BJH · UniProt Q66104
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