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B. subtilis ssba

Analyse B. subtilis ssba in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6BHW
Type: protein
Length: 794 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Single-stranded DNA-binding protein a
UniProt: P37455
Pockets: 13 · best druggability 0.64

Structure

x-ray diffraction · 8 distinct chains · 10% helix, 57% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Single-stranded DNA-binding protein a	protein	100	9% helix, 53% strand	P37455
B	Single-stranded DNA-binding protein a	protein	100	10% helix, 56% strand	P37455
C	Single-stranded DNA-binding protein a	protein	102	10% helix, 56% strand	P37455
D	Single-stranded DNA-binding protein a	protein	96	8% helix, 58% strand	P37455
E	Single-stranded DNA-binding protein a	protein	99	10% helix, 57% strand	P37455
F	Single-stranded DNA-binding protein a	protein	96	10% helix, 61% strand	P37455
G	Single-stranded DNA-binding protein a	protein	101	10% helix, 59% strand	P37455
H	Single-stranded DNA-binding protein a	protein	100	9% helix, 58% strand	P37455

Ligands and binding sites

EDO · 1,2-ethanediol · additive · 7 copies · chains A, C, D, E, F, G
PEG · Di(hydroxyethyl)ether · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

13 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	61	0.64	0.93	18	empty
2	195	0.53	0.78	33	empty
3	172	0.46	0.75	37	empty
4	93	0.46	0.80	18	EDO
5	114	0.43	0.77	25	empty

Interfaces

14 interfaces between chains.

E–F · 1504 Å² buried · 15 hydrogen bonds · protein-protein
A–B · 1363 Å² buried · 21 hydrogen bonds · protein-protein
G–H · 1325 Å² buried · 20 hydrogen bonds · protein-protein
C–D · 1288 Å² buried · 17 hydrogen bonds · protein-protein
A–D · 696 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

6BHW · B. subtilis SsbA · the same entry in another collection · chain H against H, TM-score 1.00
P37455 · AlphaFold monomer V2.0 prediction for single-stranded DNA-binding protein a (P37455) · a predicted model of the same protein · chain G against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P37455
Elsewhere: RCSB PDB 6BHW · PDBe 6BHW · UniProt P37455

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