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Structure of pfcsp peptide 20 with human antibody CIS42

Analyse Structure of pfcsp peptide 20 with human antibody CIS42 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6B5P
Type: protein
Length: 435 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pfcsp peptide 20: asn-pro-asp-pro-asn-ala-asn-pro-asn-val- asp; CIS42 Fab heavy chain…
Pockets: 2 · best druggability 0.43

Structure

x-ray diffraction · 3 distinct chains · 8% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Pfcsp peptide 20: asn-pro-asp-pro-asn-ala-asn-pro-asn-val- asp	protein	11	0% helix, 0% strand	—
H	CIS42 Fab heavy chain	protein	213	9% helix, 53% strand	—
L	CIS42 Fab light chain	protein	211	8% helix, 51% strand	—

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	184	0.43	0.73	28	empty
2	64	0.28	0.73	17	empty

Interfaces

3 interfaces between chains.

H–L · 1642 Å² buried · 12 hydrogen bonds · protein-protein
A–H · 461 Å² buried · 15 hydrogen bonds · protein-protein
A–L · 240 Å² buried · 3 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide, 1 modified (disulfide, cyclization).

Compared structures

6B5P · Structure of PfCSP peptide 20 with human antibody CIS42 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6B5P · PDBe 6B5P

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