Research workbench
Structure of pfcsp peptide 25 with human protective antibody CIS43
Analyse Structure of pfcsp peptide 25 with human protective antibody CIS43 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6B5N
- Type
- protein
- Length
- 452 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CIS43 Fab heavy chain; CIS43 Fab light chain; Pfcsp peptide 25…
- Pockets
- 3 · best druggability 0.62
Structure
x-ray diffraction · 3 distinct chains · 8% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | CIS43 Fab heavy chain | protein | 222 | 9% helix, 53% strand | — |
| L | CIS43 Fab light chain | protein | 219 | 6% helix, 53% strand | — |
| A | Pfcsp peptide 25: asn-val-asp-pro-asn-ala-asn-pro-asn-val- asp | protein | 11 | 0% helix, 9% strand | — |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 586 | 0.62 | 0.74 | 71 | empty |
| 2 | 125 | 0.41 | 0.75 | 23 | empty |
| 3 | 52 | 0.36 | 0.79 | 16 | empty |
Interfaces
3 interfaces between chains.
- H–L · 1944 Ų buried · 19 hydrogen bonds · protein-protein
- H–A · 401 Ų buried · 13 hydrogen bonds · protein-protein
- L–A · 345 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide, 1 modified (disulfide, cyclization).
Compared structures
- 6B5N · Structure of PfCSP peptide 25 with human protective antibody CIS43 · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6B5N · PDBe 6B5N
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