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Schistosoma mansoni (blood fluke) sulfotransferase, T157S mutant

Analyse Schistosoma mansoni (blood fluke) sulfotransferase, T157S mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6B4Z
Type: protein
Length: 256 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sulfotransferase oxamniquine resistance protein
EC: 2.8.2.-
UniProt: G4VLE5
Ligands: A3P
Pockets: 4 · best druggability 0.78

Structure

x-ray diffraction · 1 distinct chain · 55% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Sulfotransferase oxamniquine resistance protein (EC 2.8.2.-)	protein	256	55% helix, 7% strand	G4VLE5

Ligands and binding sites

A3P · Adenosine-3'-5'-diphosphate · ligand · chains A
TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	231	0.78	0.92	37	TRS
2	131	0.54	0.82	26	A3P
3	91	0.40	0.77	21	empty
4	93	0.33	0.73	15	empty

Modifications

Observed in the structure: 1 modified (artifact).

Compared structures

6B4Z · Schistosoma mansoni (Blood Fluke) Sulfotransferase, T157S Mutant · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G4VLE5
Elsewhere: RCSB PDB 6B4Z · PDBe 6B4Z · UniProt G4VLE5

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