Research workbench
Crystal structure of PFS25 in complex with the transmission blocking antibody 1245
Analyse Crystal structure of PFS25 in complex with the transmission blocking antibody… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6B0G
- Type
- protein
- Length
- 598 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 1245 antibody, light chain; 1245 antibody, heavy chain; 25 kda ookinete surface antigen
- UniProt
- P13829
- Pockets
- 7 · best druggability 0.78
Structure
x-ray diffraction · 3 distinct chains · 7% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | 1245 antibody, light chain | protein | 218 | 6% helix, 50% strand | — |
| D | 1245 antibody, heavy chain | protein | 226 | 10% helix, 49% strand | — |
| E | 25 kda ookinete surface antigen | protein | 154 | 4% helix, 47% strand | P13829 |
Ligands and binding sites
- GOL · Glycerol · additive · 5 copies · chains D, C, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 791 | 0.78 | 0.81 | 70 | empty |
| 2 | 283 | 0.56 | 0.77 | 40 | empty |
| 3 | 107 | 0.56 | 0.84 | 20 | GOL |
| 4 | 349 | 0.55 | 0.74 | 43 | empty |
| 5 | 159 | 0.45 | 0.75 | 20 | GOL |
Interfaces
3 interfaces between chains.
- C–D · 1943 Ų buried · 20 hydrogen bonds · protein-protein
- D–E · 667 Ų buried · 13 hydrogen bonds · protein-protein
- C–E · 240 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 14 disulfide (disulfide).
Compared structures
- 6B0G · Crystal structure of Pfs25 in complex with the transmission blocking antibody 1245 · the same entry in another collection · chain C against C, TM-score 1.00
- P13829 · AlphaFold monomer V2.0 prediction for 25 kda ookinete surface antigen (P13829) · a predicted model of the same protein · chain E against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13829
- Elsewhere: RCSB PDB 6B0G · PDBe 6B0G · UniProt P13829
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.