Crebbp bromodomain in complex with CPD17 (5-(7-(difluoromethyl)-6-(1- methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-3- METHYLBENZO[D]THIAZOL-2(3H)-one)

Structure

x-ray diffraction · 1 distinct chain.

Ligands and binding sites

• C3V · 5-[7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl]-3-methyl-1,3-benzothiazol-2(3H)-one · ligand · chains A
• SO4 · Sulfate ion · ion · 2 copies · chains A
• DMS · Dimethyl sulfoxide · additive · chains A
• GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6AY5 · CREBBP bromodomain in complex with Cpd17 (5-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-y… · the same entry in another collection · chain A against A, TM-score 1.00
• Q92793 · AlphaFold monomer V2.0 prediction for creb-binding protein (Q92793) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q92793
• Elsewhere: RCSB PDB 6AY5 · PDBe 6AY5 · UniProt Q92793