Research workbench
Cxxc and phd-type zinc finger regions of FBXL19 in complex with DNA
Analyse Cxxc and phd-type zinc finger regions of FBXL19 in complex with DNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6ASB
- Type
- protein + DNA
- Length
- 530 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA (5'-D(*GP*CP*CP*AP*AP*CP*GP*TP*TP*GP*GP*C)-3'); F-BOX/LRR-repeat protein 19
- UniProt
- Q6PCT2
- Ligands
- ZN
- Pockets
- 15 · best druggability 0.57
Structure
x-ray diffraction · 5 distinct chains · 21% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, D, E, G, H, J, K | DNA (5'-D(*GP*CP*CP*AP*AP*CP*GP*TP*TP*GP*GP*C)-3') | dna | 12 | — | — |
| C | F-BOX/LRR-repeat protein 19 | protein | 118 | 25% helix, 10% strand | Q6PCT2 |
| F | F-BOX/LRR-repeat protein 19 | protein | 85 | 18% helix, 11% strand | Q6PCT2 |
| I | F-BOX/LRR-repeat protein 19 | protein | 121 | 21% helix, 10% strand | Q6PCT2 |
| L | F-BOX/LRR-repeat protein 19 | protein | 110 | 18% helix, 11% strand | Q6PCT2 |
Ligands and binding sites
- ZN · Zinc ion · metal · 16 copies · chains C, F, I, L
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
15 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 255 | 0.57 | 0.79 | 27 | empty |
| 2 | 116 | 0.56 | 0.85 | 15 | empty |
| 3 | 133 | 0.52 | 0.81 | 15 | empty |
| 4 | 128 | 0.52 | 0.82 | 16 | empty |
| 5 | 228 | 0.47 | 0.74 | 16 | empty |
Interfaces
26 interfaces between chains.
- E–F · 618 Ų buried · 17 hydrogen bonds · protein-nucleic
- G–H · 562 Ų buried · 64 hydrogen bonds · nucleic-nucleic
- B–C · 562 Ų buried · 13 hydrogen bonds · protein-nucleic
- H–I · 561 Ų buried · 15 hydrogen bonds · protein-nucleic
- A–B · 556 Ų buried · 58 hydrogen bonds · nucleic-nucleic
Compared structures
- 6ASB · CXXC and PHD-type zinc finger regions of FBXL19 in complex with DNA · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6PCT2
- Elsewhere: RCSB PDB 6ASB · PDBe 6ASB · UniProt Q6PCT2
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.