Research workbench
CAT192 Fab insertion mutant H5/L0
Analyse CAT192 Fab insertion mutant H5/L0 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6ANP
- Type
- protein
- Length
- 852 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CAT192 Fab light chain; CAT192 Fab heavy chain
- Pockets
- 12 · best druggability 0.76
Structure
x-ray diffraction · 3 distinct chains · 6% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L, A | CAT192 Fab light chain | protein | 214 | 6% helix, 50% strand | — |
| B | CAT192 Fab heavy chain | protein | 209 | 7% helix, 49% strand | — |
| H | CAT192 Fab heavy chain | protein | 215 | 6% helix, 48% strand | — |
Pockets
12 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 616 | 0.76 | 0.82 | 81 | empty |
| 2 | 314 | 0.61 | 0.79 | 38 | empty |
| 3 | 291 | 0.60 | 0.79 | 40 | empty |
| 4 | 263 | 0.60 | 0.80 | 47 | empty |
| 5 | 216 | 0.57 | 0.80 | 23 | empty |
Interfaces
5 interfaces between chains.
- L–H · 1643 Ų buried · 7 hydrogen bonds · protein-protein
- A–B · 1629 Ų buried · 11 hydrogen bonds · protein-protein
- L–A · 1169 Ų buried · 14 hydrogen bonds · protein-protein
- L–B · 42 Ų buried · 0 hydrogen bonds · protein-protein
- A–H · 27 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide (disulfide).
Compared structures
- 6ANP · CAT192 Fab Insertion Mutant H5/L0 · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6ANP · PDBe 6ANP
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