Research workbench
CAT192 Fab wild type
Analyse CAT192 Fab wild type in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6AMJ
- Type
- protein
- Length
- 837 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CAT192 Fab light chain; CAT192 Fab heavy chain
- Ligands
- NA
- Pockets
- 12 · best druggability 0.75
Structure
x-ray diffraction · 4 distinct chains · 6% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | CAT192 Fab light chain | protein | 211 | 5% helix, 50% strand | — |
| A | CAT192 Fab light chain | protein | 214 | 6% helix, 50% strand | — |
| H | CAT192 Fab heavy chain | protein | 205 | 6% helix, 54% strand | — |
| B | CAT192 Fab heavy chain | protein | 207 | 6% helix, 50% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 895 | 0.75 | 0.79 | 90 | empty |
| 2 | 532 | 0.69 | 0.79 | 63 | empty |
| 3 | 318 | 0.58 | 0.76 | 38 | empty |
| 4 | 262 | 0.56 | 0.77 | 29 | empty |
| 5 | 215 | 0.56 | 0.79 | 24 | empty |
Interfaces
5 interfaces between chains.
- L–H · 1731 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 1664 Ų buried · 11 hydrogen bonds · protein-protein
- L–A · 1158 Ų buried · 15 hydrogen bonds · protein-protein
- A–H · 63 Ų buried · 0 hydrogen bonds · protein-protein
- L–B · 59 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 9 disulfide (disulfide).
Compared structures
- 6AMJ · CAT192 Fab Wild Type · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6AMJ · PDBe 6AMJ
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