Research workbench
Crystal structure of chorismate mutase from helicobacter pylori in complex with prephenate
Analyse Crystal structure of chorismate mutase from helicobacter pylori in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6AL9
- Type
- protein
- Length
- 181 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chorismate mutase
- UniProt
- O25064
- Ligands
- PRE, PYR, PHB
- Pockets
- 2 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 77% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chorismate mutase | protein | 90 | 77% helix, 0% strand | O25064 |
| B | Chorismate mutase | protein | 91 | 78% helix, 0% strand | O25064 |
Ligands and binding sites
- PRE · Prephenic acid · ligand · chains A, B
- PYR · Pyruvic acid · ligand · chains A, B
- PHB · P-hydroxybenzoic acid · ligand · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 151 | 0.74 | 0.92 | 22 | PRE |
| 2 | 142 | 0.73 | 0.92 | 21 | PYR, PHB |
Interfaces
1 interface between chains.
- A–B · 2490 Ų buried · 41 hydrogen bonds · protein-protein
Compared structures
- 6AL9 · Crystal structure of chorismate mutase from Helicobacter pylori in complex with prephenate · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O25064
- Elsewhere: RCSB PDB 6AL9 · PDBe 6AL9 · UniProt O25064
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