Research workbench
Crystal structure of the human natural killer cell activator receptor KIR2DS2 (CD158J)
Analyse Crystal structure of the human natural killer cell activator receptor KIR2DS2… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1M4K
- Type
- protein
- Length
- 193 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Killer cell immunoglobulin-like receptor 2DS2
- UniProt
- P43631
- Ligands
- SO4
- Pockets
- 3 · best druggability 0.51
Structure
x-ray diffraction · 1 distinct chain · 2% helix, 54% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Killer cell immunoglobulin-like receptor 2DS2 | protein | 193 | 2% helix, 54% strand | P43631 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 250 | 0.51 | 0.75 | 42 | empty |
| 2 | 67 | 0.38 | 0.79 | 17 | empty |
| 3 | 59 | 0.33 | 0.76 | 15 | empty |
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 1M4K · Crystal structure of the human natural killer cell activator receptor KIR2DS2 (CD158j) · the same entry in another collection · chain A against A, TM-score 1.00
- P43631 · AlphaFold monomer V2.0 prediction for killer cell immunoglobulin-like receptor 2DS2… · a predicted model of the same protein · chain A against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43631
- Elsewhere: RCSB PDB 1M4K · PDBe 1M4K · UniProt P43631
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