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Crystal structure of EFHA2 in apo state

Analyse Crystal structure of EFHA2 in apo state in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6AGJ
Type: protein
Length: 624 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Calcium uptake protein 3, mitochondrial
UniProt: Q86XE3
Pockets: 10 · best druggability 0.75

Structure

x-ray diffraction · 2 distinct chains · 62% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Calcium uptake protein 3, mitochondrial	protein	309	61% helix, 7% strand	Q86XE3
B	Calcium uptake protein 3, mitochondrial	protein	315	64% helix, 7% strand	Q86XE3

Pockets

10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	260	0.75	0.88	37	empty
2	266	0.73	0.87	34	empty
3	490	0.69	0.80	48	empty
4	295	0.67	0.82	27	empty
5	120	0.57	0.84	22	empty

Interfaces

1 interface between chains.

A–B · 1512 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

6AGJ · Crystal Structure of EFHA2 in Apo State · the same entry in another collection · chain A against A, TM-score 1.00
Q86XE3 · AlphaFold monomer V2.0 prediction for calcium uptake protein 3, mitochondrial (Q86XE3) · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q86XE3
Elsewhere: RCSB PDB 6AGJ · PDBe 6AGJ · UniProt Q86XE3

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