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Crystal structure of class a B-lactamase, penl, variant ASN136ASP, from burkholderia thailandensis
Analyse Crystal structure of class a B-lactamase, penl, variant ASN136ASP, from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6AFO
- Type
- protein
- Length
- 536 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Beta-lactamase
- EC
- 3.5.2.6
- UniProt
- A0A2Z4SUB5
- Pockets
- 3 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Beta-lactamase (EC 3.5.2.6) | protein | 268 | 44% helix, 20% strand | A0A2Z4SUB5 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1158 | 0.74 | 0.77 | 105 | empty |
| 2 | 61 | 0.31 | 0.76 | 15 | empty |
| 3 | 87 | 0.31 | 0.73 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 594 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 6AFO · Crystal structure of class A b-lactamase, PenL, variant Asn136Asp, from Burkholderia… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A2Z4SUB5
- Elsewhere: RCSB PDB 6AFO · PDBe 6AFO · UniProt A0A2Z4SUB5
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