Research workbench
Structure of CTR9, PAF1 and CDC73 ternary complex from myceliophthora thermophila
Analyse Structure of CTR9, PAF1 and CDC73 ternary complex from myceliophthora… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6AF0
- Type
- protein
- Length
- 1,054 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CTR9 protein; PAF1 protein; CDC73 protein
- UniProt
- G2QC65, G2QDK9, G2Q3X1
- Pockets
- 11 · best druggability 0.75
Structure
x-ray diffraction · 3 distinct chains · 68% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | CTR9 protein | protein | 905 | 75% helix, 1% strand | G2QC65 |
| P | PAF1 protein | protein | 107 | 21% helix, 3% strand | G2QDK9 |
| C | CDC73 protein | protein | 42 | 43% helix, 5% strand | G2Q3X1 |
Pockets
11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 575 | 0.75 | 0.82 | 52 | empty |
| 2 | 1188 | 0.72 | 0.76 | 117 | empty |
| 3 | 387 | 0.65 | 0.79 | 39 | empty |
| 4 | 499 | 0.62 | 0.76 | 57 | empty |
| 5 | 88 | 0.49 | 0.82 | 21 | empty |
Interfaces
3 interfaces between chains.
- A–P · 6028 Ų buried · 74 hydrogen bonds · protein-protein
- A–C · 1872 Ų buried · 29 hydrogen bonds · protein-protein
- P–C · 464 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 6AF0 · Structure of Ctr9, Paf1 and Cdc73 ternary complex from Myceliophthora thermophila · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G2QC65
- Every structure of UniProt G2QDK9
- Every structure of UniProt G2Q3X1
- Elsewhere: RCSB PDB 6AF0 · PDBe 6AF0 · UniProt G2QC65 · UniProt G2QDK9 · UniProt G2Q3X1
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