Research workbench
The structure of [4+2] and [6+4] cyclase in the biosynthetic pathway of streptoseomycin
Analyse The structure of [4+2] and [6+4] cyclase in the biosynthetic pathway of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6A5G
- Type
- protein
- Length
- 607 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- [4+2] and [4+6] cyclase stmd
- Pockets
- 11 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 25% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, D | [4+2] and [4+6] cyclase stmd | protein | 150 | 26% helix, 40% strand | — |
| B | [4+2] and [4+6] cyclase stmd | protein | 157 | 24% helix, 36% strand | — |
Pockets
11 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 299 | 0.72 | 0.85 | 35 | empty |
| 2 | 90 | 0.72 | 0.95 | 24 | empty |
| 3 | 67 | 0.71 | 0.96 | 19 | empty |
| 4 | 265 | 0.69 | 0.84 | 36 | empty |
| 5 | 275 | 0.67 | 0.82 | 40 | empty |
Interfaces
6 interfaces between chains.
- A–D · 1079 Ų buried · 8 hydrogen bonds · protein-protein
- C–B · 1056 Ų buried · 12 hydrogen bonds · protein-protein
- A–B · 706 Ų buried · 10 hydrogen bonds · protein-protein
- C–D · 701 Ų buried · 13 hydrogen bonds · protein-protein
- A–C · 204 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 6A5G · The structure of [4+2] and [6+4] cyclase in the biosynthetic pathway of streptoseomycin · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6A5G · PDBe 6A5G
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