Research workbench
Architectural roles of CREN7 in folding crenarchaeal chromatin filament
Analyse Architectural roles of CREN7 in folding crenarchaeal chromatin filament in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6A2I
- Type
- protein + DNA
- Length
- 149 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chromatin protein CREN7; DNA (5'- D(*CP*GP*TP*AP*GP*CP*TP*AP*AP*TP*TP*AP*GP*CP*TP*AP*CP*G)…
- UniProt
- Q97ZE3
- Pockets
- 2 · best druggability 0.42
Structure
x-ray diffraction · 3 distinct chains · 0% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chromatin protein CREN7 | protein | 56 | 0% helix, 45% strand | Q97ZE3 |
| B | Chromatin protein CREN7 | protein | 57 | 0% helix, 46% strand | Q97ZE3 |
| C, D | DNA (5'- D(*CP*GP*TP*AP*GP*CP*TP*AP*AP*TP*TP*AP*GP*CP*TP*AP*CP*G)-3') | dna | 18 | — | — |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 143 | 0.42 | 0.75 | 18 | empty |
| 2 | 95 | 0.36 | 0.75 | 16 | empty |
Interfaces
5 interfaces between chains.
- C–D · 818 Ų buried · 91 hydrogen bonds · nucleic-nucleic
- A–C · 556 Ų buried · 9 hydrogen bonds · protein-nucleic
- B–C · 467 Ų buried · 4 hydrogen bonds · protein-nucleic
- B–D · 403 Ų buried · 4 hydrogen bonds · protein-nucleic
- A–D · 368 Ų buried · 1 hydrogen bond · protein-nucleic
Compared structures
- 6A2I · Architectural roles of Cren7 in folding crenarchaeal chromatin filament · the same entry in another collection · chain A against A, TM-score 1.00
- Q97ZE3 · AlphaFold monomer V2.0 prediction for chromatin protein CREN7 (Q97ZE3) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q97ZE3
- Elsewhere: RCSB PDB 6A2I · PDBe 6A2I · UniProt Q97ZE3
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