Research workbench

Mandelate oxidase mutant-Y128F with benzaldehyde

Analyse Mandelate oxidase mutant-Y128F with benzaldehyde in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6A0O
Type: protein
Length: 332 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 4-hydroxymandelate oxidase
EC: 1.1.3.46
UniProt: O52792
Ligands: HBX, FMN
Pockets: 3 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 45% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	4-hydroxymandelate oxidase (EC 1.1.3.46)	protein	332	45% helix, 14% strand	O52792

Ligands and binding sites

HBX · benzaldehyde · ligand · 3 copies · chains A
FMN · Flavin mononucleotide · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	213	0.76	0.91	35	FMN, HBX
2	88	0.35	0.74	15	empty
3	55	0.32	0.76	12	empty

Compared structures

6A0O · Mandelate oxidase mutant-Y128F with benzaldehyde · the same entry in another collection · chain A against A, TM-score 1.00
O52792 · AlphaFold monomer V2.0 prediction for 4-hydroxymandelate oxidase (O52792) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O52792
Elsewhere: RCSB PDB 6A0O · PDBe 6A0O · UniProt O52792

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