Research workbench
Crystal structure of HOMER2 EVH1/DREBRIN ppxxf complex
Analyse Crystal structure of HOMER2 EVH1/DREBRIN ppxxf complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5ZZ9
- Type
- protein
- Length
- 387 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Homer protein homolog 2; Peptide from drebrin
- UniProt
- Q9QWW1, Q16643
- Pockets
- 1 · best druggability 0.26
Structure
x-ray diffraction · 5 distinct chains · 19% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Homer protein homolog 2 | protein | 114 | 19% helix, 51% strand | Q9QWW1 |
| C | Homer protein homolog 2 | protein | 113 | 19% helix, 49% strand | Q9QWW1 |
| D | Peptide from drebrin | protein | 15 | 20% helix, 0% strand | Q16643 |
| E | Peptide from drebrin | protein | 19 | 16% helix, 0% strand | Q16643 |
| F | Peptide from drebrin | protein | 12 | 25% helix, 0% strand | Q16643 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 51 | 0.26 | 0.74 | 16 | empty |
Interfaces
5 interfaces between chains.
- A–C · 636 Ų buried · 12 hydrogen bonds · protein-protein
- A–E · 604 Ų buried · 5 hydrogen bonds · protein-protein
- A–B · 526 Ų buried · 8 hydrogen bonds · protein-protein
- B–D · 479 Ų buried · 4 hydrogen bonds · protein-protein
- C–F · 428 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 5ZZ9 · Crystal structure of Homer2 EVH1/Drebrin PPXXF complex · the same entry in another collection · chain F against F, TM-score 1.00
- Q9QWW1 · AlphaFold monomer V2.0 prediction for homer protein homolog 2 (Q9QWW1) · a predicted model of the same protein · chain C against A, TM-score 0.98
- Q16643 · AlphaFold monomer V2.0 prediction for drebrin (Q16643) · a predicted model of the same protein · chain F against A, TM-score 0.36
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9QWW1
- Every structure of UniProt Q16643
- Elsewhere: RCSB PDB 5ZZ9 · PDBe 5ZZ9 · UniProt Q9QWW1 · UniProt Q16643
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