Research workbench
Crystal structure of K132A mutant of phosphomannose isomerase from salmonella typhimurium
Analyse Crystal structure of K132A mutant of phosphomannose isomerase from salmonella… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5ZVU
- Type
- protein
- Length
- 381 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mannose-6-phosphate isomerase
- EC
- 5.3.1.8
- UniProt
- P25081
- Ligands
- ZN
- Pockets
- 2 · best druggability 0.61
Structure
x-ray diffraction · 1 distinct chain · 31% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mannose-6-phosphate isomerase (EC 5.3.1.8) | protein | 381 | 31% helix, 32% strand | P25081 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 313 | 0.61 | 0.79 | 38 | ZN, EDO |
| 2 | 66 | 0.32 | 0.76 | 18 | empty |
Compared structures
- 5ZVU · Crystal structure of K132A mutant of phosphomannose isomerase from Salmonella typhimurium · the same entry in another collection · chain A against A, TM-score 1.00
- P25081 · AlphaFold monomer V2.0 prediction for mannose-6-phosphate isomerase (P25081) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P25081
- Elsewhere: RCSB PDB 5ZVU · PDBe 5ZVU · UniProt P25081
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