Research workbench
Crystal structure analysis of the peptide amidase pam in complex with the competitive inhibitor chymostatin
Analyse Crystal structure analysis of the peptide amidase pam in complex with the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1M21
- Type
- protein
- Length
- 982 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Peptide amidase; Chymostatin
- EC
- 3.5.1.-
- UniProt
- Q8RJN5
- Pockets
- 6 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Peptide amidase (EC 3.5.1.-) | protein | 487 | 40% helix, 15% strand | Q8RJN5 |
| C, D | Chymostatin | protein | 4 | 0% helix, 0% strand | — |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 100 | 0.61 | 0.88 | 30 | empty |
| 2 | 155 | 0.54 | 0.80 | 42 | empty |
| 3 | 224 | 0.52 | 0.76 | 50 | empty |
| 4 | 82 | 0.42 | 0.80 | 14 | empty |
| 5 | 56 | 0.37 | 0.80 | 11 | empty |
Interfaces
3 interfaces between chains.
- A–C · 493 Ų buried · 6 hydrogen bonds · protein-protein
- B–D · 491 Ų buried · 5 hydrogen bonds · protein-protein
- A–B · 28 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 modified (nonstandard).
Compared structures
- 1M21 · Crystal structure analysis of the peptide amidase PAM in complex with the competitive… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8RJN5
- Elsewhere: RCSB PDB 1M21 · PDBe 1M21 · UniProt Q8RJN5
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.