Research workbench
Crystal structure of prxa C119S mutant from arabidopsis thaliana
Analyse Crystal structure of prxa C119S mutant from arabidopsis thaliana in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5ZTE
- Type
- protein
- Length
- 1,939 residues
- Chains
- 10
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 2-cys peroxiredoxin BAS1, chloroplastic
- EC
- 1.11.1.15
- UniProt
- Q96291
- Pockets
- 20 · best druggability 0.70
Structure
x-ray diffraction · 6 distinct chains · 29% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D | 2-cys peroxiredoxin BAS1, chloroplastic (EC 1.11.1.15) | protein | 195 | 29% helix, 25% strand | Q96291 |
| B | 2-cys peroxiredoxin BAS1, chloroplastic (EC 1.11.1.15) | protein | 198 | 28% helix, 26% strand | Q96291 |
| C, H | 2-cys peroxiredoxin BAS1, chloroplastic (EC 1.11.1.15) | protein | 193 | 30% helix, 26% strand | Q96291 |
| E, I, J | 2-cys peroxiredoxin BAS1, chloroplastic (EC 1.11.1.15) | protein | 194 | 30% helix, 26% strand | Q96291 |
| F | 2-cys peroxiredoxin BAS1, chloroplastic (EC 1.11.1.15) | protein | 196 | 29% helix, 25% strand | Q96291 |
| G | 2-cys peroxiredoxin BAS1, chloroplastic (EC 1.11.1.15) | protein | 187 | 28% helix, 28% strand | Q96291 |
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 54 | 0.70 | 0.98 | 22 | empty |
| 2 | 1107 | 0.70 | 0.74 | 108 | empty |
| 3 | 778 | 0.67 | 0.74 | 86 | empty |
| 4 | 268 | 0.58 | 0.78 | 38 | empty |
| 5 | 242 | 0.57 | 0.78 | 34 | empty |
Interfaces
16 interfaces between chains.
- I–J · 1969 Ų buried · 22 hydrogen bonds · protein-protein
- B–C · 1937 Ų buried · 28 hydrogen bonds · protein-protein
- D–E · 1870 Ų buried · 21 hydrogen bonds · protein-protein
- G–H · 1728 Ų buried · 20 hydrogen bonds · protein-protein
- F–G · 611 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 5ZTE · Crystal structure of PrxA C119S mutant from Arabidopsis thaliana · the same entry in another collection · chain J against J, TM-score 1.00
- Q96291 · AlphaFold monomer V2.0 prediction for 2-cys peroxiredoxin BAS1, chloroplastic (Q96291) · a predicted model of the same protein · chain E against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96291
- Elsewhere: RCSB PDB 5ZTE · PDBe 5ZTE · UniProt Q96291
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