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Crystal structure of E134A mutant of phosphomannose isomerase from salmonella typhimurium

Analyse Crystal structure of E134A mutant of phosphomannose isomerase from salmonella… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5ZT5
Type: protein
Length: 392 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mannose-6-phosphate isomerase
EC: 5.3.1.8
UniProt: P25081
Pockets: 2 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 30% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mannose-6-phosphate isomerase (EC 5.3.1.8)	protein	392	30% helix, 31% strand	P25081

Ligands and binding sites

EDO · 1,2-ethanediol · additive · 5 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	349	0.64	0.79	38	EDO
2	52	0.29	0.76	14	EDO

Compared structures

5ZT5 · Crystal structure of E134A mutant of phosphomannose isomerase from Salmonella typhimurium · the same entry in another collection · chain A against A, TM-score 1.00
P25081 · AlphaFold monomer V2.0 prediction for mannose-6-phosphate isomerase (P25081) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P25081
Elsewhere: RCSB PDB 5ZT5 · PDBe 5ZT5 · UniProt P25081

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