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Crystal structure of human C1ORF123 protein

Analyse Crystal structure of human C1ORF123 protein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5ZRT
Type: protein
Length: 320 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: UPF0587 protein C1ORF123
UniProt: Q9NWV4
Ligands: ZN, CL
Pockets: 5 · best druggability 0.69

Structure

x-ray diffraction · 1 distinct chain · 6% helix, 57% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	UPF0587 protein C1ORF123	protein	160	6% helix, 57% strand	Q9NWV4

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A, B
CL · Chloride ion · ion · 2 copies · chains A, B
GOL · Glycerol · additive · 6 copies · chains A, B
BME · Beta-mercaptoethanol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	60	0.69	0.96	20	empty
2	241	0.51	0.75	30	empty
3	244	0.50	0.75	31	empty
4	101	0.46	0.80	23	GOL
5	52	0.37	0.80	15	empty

Interfaces

1 interface between chains.

A–B · 595 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

5ZRT · Crystal structure of human C1ORF123 protein · the same entry in another collection · chain A against A, TM-score 1.00
Q9NWV4 · AlphaFold monomer V2.0 prediction for cxxc motif containing zinc binding protein (Q9NWV4) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NWV4
Elsewhere: RCSB PDB 5ZRT · PDBe 5ZRT · UniProt Q9NWV4

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