Research workbench
X-ray crystal structure of mycobacterium tuberculosis beta- ketoacyl-acyl carrier protein synthase III (mtfabh)
Analyse X-ray crystal structure of mycobacterium tuberculosis beta- ketoacyl-acyl… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1M1M
- Type
- protein
- Length
- 661 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 3-oxoacyl-[acyl-carrier-protein] synthase III
- EC
- 2.3.1.41
- UniProt
- P0A574
- Pockets
- 9 · best druggability 0.81
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 3-oxoacyl-[acyl-carrier-protein] synthase III (EC 2.3.1.41) | protein | 332 | 36% helix, 25% strand | P0A574 |
| B | 3-oxoacyl-[acyl-carrier-protein] synthase III (EC 2.3.1.41) | protein | 329 | 36% helix, 24% strand | P0A574 |
Pockets
9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 138 | 0.81 | 0.99 | 26 | empty |
| 2 | 169 | 0.63 | 0.84 | 24 | empty |
| 3 | 93 | 0.51 | 0.83 | 29 | empty |
| 4 | 85 | 0.51 | 0.83 | 27 | empty |
| 5 | 85 | 0.42 | 0.79 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 2964 Ų buried · 38 hydrogen bonds · protein-protein
Compared structures
- 1M1M · X-ray crystal structure of mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A574
- Elsewhere: RCSB PDB 1M1M · PDBe 1M1M · UniProt P0A574
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