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Crystal structure of glutamine synthetase from helicobacter pylori

Analyse Crystal structure of glutamine synthetase from helicobacter pylori in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5ZLI
Type: protein
Length: 2,846 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glutamine synthetase
EC: 6.3.1.2
UniProt: P94845
Pockets: 20 · best druggability 0.80

Structure

x-ray diffraction · 2 distinct chains · 35% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C, E, F	Glutamine synthetase (EC 6.3.1.2)	protein	474	35% helix, 23% strand	P94845
B, D	Glutamine synthetase (EC 6.3.1.2)	protein	475	35% helix, 24% strand	P94845

Pockets

20 pockets found on a 1 Å grid, 18 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	963	0.80	0.82	73	empty
2	978	0.80	0.82	75	empty
3	938	0.80	0.82	72	empty
4	1084	0.79	0.80	69	empty
5	1084	0.78	0.79	73	empty

Interfaces

6 interfaces between chains.

A–B · 1963 Å² buried · 42 hydrogen bonds · protein-protein
A–F · 1921 Å² buried · 41 hydrogen bonds · protein-protein
D–E · 1914 Å² buried · 39 hydrogen bonds · protein-protein
E–F · 1901 Å² buried · 38 hydrogen bonds · protein-protein
C–D · 1894 Å² buried · 41 hydrogen bonds · protein-protein

Compared structures

5ZLI · Crystal structure of glutamine synthetase from helicobacter pylori · the same entry in another collection · chain F against F, TM-score 1.00
P94845 · AlphaFold monomer V2.0 prediction for glutamine synthetase (P94845) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P94845
Elsewhere: RCSB PDB 5ZLI · PDBe 5ZLI · UniProt P94845

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