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Crystal structure of the red light-activated channelrhodopsin chrimson.
Analyse Crystal structure of the red light-activated channelrhodopsin chrimson. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5ZIH
- Type
- protein
- Length
- 564 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sensory opsin A,CHRIMSON
- UniProt
- Q8L435
- Pockets
- 10 · best druggability 0.64
Structure
x-ray diffraction · 2 distinct chains · 65% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sensory opsin A,CHRIMSON | protein | 279 | 65% helix, 9% strand | Q8L435 |
| B | Sensory opsin A,CHRIMSON | protein | 285 | 64% helix, 9% strand | Q8L435 |
Ligands and binding sites
- OLC · (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate · additive · 19 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 162 | 0.64 | 0.85 | 20 | OLC |
| 2 | 188 | 0.62 | 0.82 | 26 | OLC |
| 3 | 195 | 0.56 | 0.79 | 33 | empty |
| 4 | 122 | 0.51 | 0.81 | 21 | empty |
| 5 | 263 | 0.51 | 0.74 | 28 | OLC |
Interfaces
1 interface between chains.
- A–B · 2090 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide, 2 modified (disulfide, nonstandard).
Compared structures
- 5ZIH · Crystal structure of the red light-activated channelrhodopsin Chrimson. · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8L435
- Elsewhere: RCSB PDB 5ZIH · PDBe 5ZIH · UniProt Q8L435
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