Research workbench
Structural characterization of the hcov-229E fusion core
Analyse Structural characterization of the hcov-229E fusion core in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5ZHY
- Type
- protein
- Length
- 535 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Spike glycoprotein, spike glycoprotein
- UniProt
- P15423
- Pockets
- 2 · best druggability 0.65
Structure
x-ray diffraction · 6 distinct chains · 87% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Spike glycoprotein, spike glycoprotein | protein | 90 | 89% helix, 0% strand | P15423 |
| B | Spike glycoprotein, spike glycoprotein | protein | 89 | 87% helix, 0% strand | P15423 |
| C | Spike glycoprotein, spike glycoprotein | protein | 89 | 87% helix, 0% strand | P15423 |
| D | Spike glycoprotein, spike glycoprotein | protein | 90 | 87% helix, 0% strand | P15423 |
| E | Spike glycoprotein, spike glycoprotein | protein | 88 | 89% helix, 0% strand | P15423 |
| F | Spike glycoprotein, spike glycoprotein | protein | 89 | 85% helix, 0% strand | P15423 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 397 | 0.65 | 0.79 | 57 | empty |
| 2 | 81 | 0.56 | 0.86 | 17 | empty |
Interfaces
10 interfaces between chains.
- A–C · 1396 Ų buried · 6 hydrogen bonds · protein-protein
- E–F · 1395 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 1390 Ų buried · 9 hydrogen bonds · protein-protein
- D–F · 1376 Ų buried · 8 hydrogen bonds · protein-protein
- A–B · 1335 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 5ZHY · Structural characterization of the HCoV-229E fusion core · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15423
- Elsewhere: RCSB PDB 5ZHY · PDBe 5ZHY · UniProt P15423
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