Research workbench
Nmnat as a specific chaperone antagonizing pathological condensation of phosphorylated tau
Analyse Nmnat as a specific chaperone antagonizing pathological condensation of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5Z9R
- Type
- protein
- Length
- 435 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NICOTINAMIDE/NICOTINIC acid mononucleotide adenylyltransferase 3
- EC
- 2.7.7.1, 2.7.7.18
- UniProt
- Q99JR6
- Pockets
- 5 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 46% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NICOTINAMIDE/NICOTINIC acid mononucleotide adenylyltransferase 3 (EC 2.7.7.1, 2.7.7.18) | protein | 217 | 47% helix, 18% strand | Q99JR6 |
| B | NICOTINAMIDE/NICOTINIC acid mononucleotide adenylyltransferase 3 (EC 2.7.7.1, 2.7.7.18) | protein | 218 | 45% helix, 19% strand | Q99JR6 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 361 | 0.68 | 0.81 | 39 | empty |
| 2 | 412 | 0.64 | 0.78 | 42 | empty |
| 3 | 208 | 0.61 | 0.82 | 23 | empty |
| 4 | 111 | 0.38 | 0.75 | 19 | empty |
| 5 | 77 | 0.30 | 0.73 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1138 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 5Z9R · NMNAT as a specific chaperone antagonizing pathological condensation of phosphorylated tau · the same entry in another collection · chain A against A, TM-score 1.00
- Q99JR6 · AlphaFold monomer V2.0 prediction for NICOTINAMIDE/NICOTINIC acid mononucleotide… · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99JR6
- Elsewhere: RCSB PDB 5Z9R · PDBe 5Z9R · UniProt Q99JR6
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