Research workbench
The crystal structure of kinetochore subunits cenp-H/I/K triple complex
Analyse The crystal structure of kinetochore subunits cenp-H/I/K triple complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5Z08
- Type
- protein
- Length
- 574 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cenp-I; Cenp-K; Cenp-H
- UniProt
- G0SFF7, G2R3T1, G2R207
- Pockets
- 6 · best druggability 0.74
Structure
x-ray diffraction · 3 distinct chains · 64% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Cenp-I | protein | 214 | 66% helix, 2% strand | G0SFF7 |
| C | Cenp-K | protein | 102 | 60% helix, 9% strand | G2R3T1 |
| D | Cenp-H | protein | 44 | 66% helix, 0% strand | G2R207 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 559 | 0.74 | 0.82 | 62 | empty |
| 2 | 85 | 0.72 | 0.96 | 22 | empty |
| 3 | 127 | 0.45 | 0.77 | 27 | empty |
| 4 | 54 | 0.43 | 0.83 | 15 | empty |
| 5 | 88 | 0.36 | 0.75 | 15 | empty |
Interfaces
4 interfaces between chains.
- C–D · 1541 Ų buried · 6 hydrogen bonds · protein-protein
- A–B · 905 Ų buried · 12 hydrogen bonds · protein-protein
- B–D · 678 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 419 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 5Z08 · The crystal structure of kinetochore subunits Cenp-H/I/K triple complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0SFF7
- Every structure of UniProt G2R3T1
- Every structure of UniProt G2R207
- Elsewhere: RCSB PDB 5Z08 · PDBe 5Z08 · UniProt G0SFF7 · UniProt G2R3T1 · UniProt G2R207
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