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The post-fusion structure of the heartland virus gc glycoprotein

Analyse The post-fusion structure of the heartland virus gc glycoprotein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5YOW
Type: protein
Length: 425 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glycoprotein polyprotein
UniProt: J3SPZ8
Ligands: NAG, FUC
Pockets: 4 · best druggability 0.40

Structure

x-ray diffraction · 1 distinct chain · 5% helix, 54% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glycoprotein polyprotein	protein	425	5% helix, 54% strand	J3SPZ8

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A
FUC · alpha-L-fucopyranose · sugar · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	132	0.40	0.74	21	FUC
2	101	0.39	0.76	19	empty
3	66	0.32	0.75	14	empty
4	62	0.30	0.75	20	empty

Modifications

Observed in the structure: 13 disulfide, 1 glycan (disulfide, N-glycosylation).

Compared structures

5YOW · The post-fusion structure of the Heartland virus Gc glycoprotein · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt J3SPZ8
Elsewhere: RCSB PDB 5YOW · PDBe 5YOW · UniProt J3SPZ8

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