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Mycobacterium tuberculosis methionine aminopeptidase type 1C (C105T mutant) in complex with methionine

Analyse Mycobacterium tuberculosis methionine aminopeptidase type 1C (C105T mutant) in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5YOI
Type: protein
Length: 282 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Methionine aminopeptidase
EC: 3.4.11.18
UniProt: A5U6L5
Ligands: MET, CO, NA
Pockets: 2 · best druggability 0.56

Structure

x-ray diffraction · 1 distinct chain · 24% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Methionine aminopeptidase (EC 3.4.11.18)	protein	282	24% helix, 24% strand	A5U6L5

Ligands and binding sites

MET · Methionine · ligand · chains A
CO · Cobalt (II) ion · metal · 2 copies · chains A
NA · Sodium ion · metal · chains A
GOL · Glycerol · additive · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	161	0.56	0.81	26	MET
2	78	0.38	0.77	16	empty

Compared structures

5YOI · Mycobacterium Tuberculosis Methionine aminopeptidase type 1c (C105T mutant) in complex… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A5U6L5
Elsewhere: RCSB PDB 5YOI · PDBe 5YOI · UniProt A5U6L5

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