Research workbench

Crystal structure of the DNA-binding domain of human myelin-gene regulatory factor

Analyse Crystal structure of the DNA-binding domain of human myelin-gene regulatory… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5YHU
Type: protein
Length: 373 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Myelin regulatory factor
EC: 3.4.-.-
UniProt: Q9Y2G1
Pockets: 3 · best druggability 0.43

Structure

x-ray diffraction · 2 distinct chains · 2% helix, 55% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Myelin regulatory factor (EC 3.4.-.-)	protein	191	2% helix, 55% strand	Q9Y2G1
B	Myelin regulatory factor (EC 3.4.-.-)	protein	182	2% helix, 55% strand	Q9Y2G1

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	96	0.43	0.78	18	empty
2	57	0.31	0.76	12	empty
3	52	0.30	0.76	14	empty

Interfaces

1 interface between chains.

A–B · 220 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

5YHU · Crystal structure of the DNA-binding domain of human myelin-gene regulatory factor · the same entry in another collection · chain A against A, TM-score 1.00
Q9Y2G1 · AlphaFold monomer V2.0 prediction for myelin regulatory factor (Q9Y2G1) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9Y2G1
Elsewhere: RCSB PDB 5YHU · PDBe 5YHU · UniProt Q9Y2G1

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.