Research workbench
Crystal structure of acetolactate decarboxylase from enterobacter cloacae
Analyse Crystal structure of acetolactate decarboxylase from enterobacter cloacae in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5YHO
- Type
- protein
- Length
- 473 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alpha-acetolactate decarboxylase
- EC
- 4.1.1.5
- UniProt
- P05361
- Ligands
- ZN, CL
- Pockets
- 5 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 16% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Alpha-acetolactate decarboxylase (EC 4.1.1.5) | protein | 238 | 17% helix, 42% strand | P05361 |
| B | Alpha-acetolactate decarboxylase (EC 4.1.1.5) | protein | 235 | 16% helix, 43% strand | P05361 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 63 | 0.71 | 0.97 | 20 | CL |
| 2 | 193 | 0.54 | 0.79 | 28 | empty |
| 3 | 90 | 0.35 | 0.75 | 17 | empty |
| 4 | 57 | 0.30 | 0.75 | 15 | empty |
| 5 | 54 | 0.25 | 0.73 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 1162 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 5YHO · Crystal structure of acetolactate decarboxylase from Enterobacter cloacae · the same entry in another collection · chain A against A, TM-score 1.00
- P05361 · AlphaFold monomer V2.0 prediction for alpha-acetolactate decarboxylase (P05361) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05361
- Elsewhere: RCSB PDB 5YHO · PDBe 5YHO · UniProt P05361
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