Research workbench
Structural and mechanistic analyses reveal a unique CAS4-like protein in the mimivirus virophage resistance element system
Analyse Structural and mechanistic analyses reveal a unique CAS4-like protein in the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5YEU
- Type
- protein
- Length
- 762 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uncharacterized protein R354
- UniProt
- Q5UQV1
- Ligands
- MG
- Pockets
- 10 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Uncharacterized protein R354 | protein | 381 | 43% helix, 19% strand | Q5UQV1 |
| B | Uncharacterized protein R354 | protein | 381 | 41% helix, 19% strand | Q5UQV1 |
Ligands and binding sites
- MG · Magnesium ion · metal · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 872 | 0.76 | 0.79 | 68 | MG |
| 2 | 534 | 0.66 | 0.77 | 61 | MG |
| 3 | 233 | 0.56 | 0.78 | 22 | empty |
| 4 | 260 | 0.53 | 0.76 | 23 | empty |
| 5 | 211 | 0.53 | 0.77 | 30 | empty |
Interfaces
1 interface between chains.
- A–B · 1164 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 5YEU · Structural and mechanistic analyses reveal a unique Cas4-like protein in the mimivirus… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5UQV1
- Elsewhere: RCSB PDB 5YEU · PDBe 5YEU · UniProt Q5UQV1
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