Research workbench
Crystal structure of mitochondrial alcohol dehydrogenase isozyme III from komagataella phaffii GS115
Analyse Crystal structure of mitochondrial alcohol dehydrogenase isozyme III from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5YAT
- Type
- protein
- Length
- 694 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitochondrial alcohol dehydrogenase isozyme III
- UniProt
- C4R0S8
- Ligands
- ZN
- Pockets
- 6 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain · 30% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Mitochondrial alcohol dehydrogenase isozyme III | protein | 347 | 30% helix, 26% strand | C4R0S8 |
Ligands and binding sites
- ZN · Zinc ion · metal · 4 copies · chains A, B
- GOL · Glycerol · additive · 4 copies · chains A, B
- IPA · Isopropyl alcohol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 602 | 0.74 | 0.81 | 54 | GOL |
| 2 | 598 | 0.74 | 0.81 | 58 | GOL |
| 3 | 327 | 0.68 | 0.83 | 42 | empty |
| 4 | 66 | 0.47 | 0.84 | 20 | empty |
| 5 | 101 | 0.46 | 0.80 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 763 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 5YAT · Crystal structure of mitochondrial alcohol dehydrogenase isozyme III from Komagataella… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C4R0S8
- Elsewhere: RCSB PDB 5YAT · PDBe 5YAT · UniProt C4R0S8
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