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Recombinant human diferric lactoferrin

Analyse Recombinant human diferric lactoferrin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1B0L
Type: protein
Length: 691 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (lactoferrin)
UniProt: P02788
Ligands: FE, CO3
Pockets: 12 · best druggability 0.78

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein (lactoferrin)	protein	691	37% helix, 19% strand	P02788

Ligands and binding sites

FE · Fe (III) ion · metal · 2 copies · chains A
CO3 · Carbonate ion · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

12 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	287	0.78	0.90	38	empty
2	253	0.76	0.89	37	empty
3	259	0.61	0.80	28	empty
4	145	0.53	0.80	26	empty
5	187	0.51	0.77	28	empty

Modifications

Observed in the structure: 16 disulfide (disulfide).

Compared structures

1B0L · Recombinant human diferric lactoferrin · the same entry in another collection · chain A against A, TM-score 1.00
P02788 · AlphaFold monomer V2.0 prediction for lactotransferrin (P02788) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P02788
Elsewhere: RCSB PDB 1B0L · PDBe 1B0L · UniProt P02788

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