Research workbench
Crystal structure of the L52M mutant of ACRIIA1
Analyse Crystal structure of the L52M mutant of ACRIIA1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5Y69
- Type
- protein
- Length
- 292 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chain a
- Pockets
- 3 · best druggability 0.36
Structure
x-ray diffraction · 2 distinct chains · 72% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chain a | protein | 147 | 73% helix, 1% strand | — |
| B | Chain a | protein | 145 | 70% helix, 1% strand | — |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 78 | 0.36 | 0.76 | 21 | empty |
| 2 | 73 | 0.35 | 0.77 | 17 | empty |
| 3 | 75 | 0.32 | 0.74 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1357 Ų buried · 19 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 modified (engineered).
Compared structures
- 5Y69 · Crystal structure of the L52M mutant of AcrIIA1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 5Y69 · PDBe 5Y69
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