Research workbench

Structure of tar RNA complexed with a tat-tar interaction nanomolar inhibitor that was identified by computational screening

Analyse Structure of tar RNA complexed with a tat-tar interaction nanomolar inhibitor… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1LVJ
Type: RNA
Length: 31 nucleotides
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: HIV-1 trans activating region RNA
Ligands: PMZ
Pockets: 1 · best druggability 0.32

Structure

solution nmr · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	HIV-1 trans activating region RNA	rna	31	—	—

Ligands and binding sites

PMZ · 1-[10-(3-dimethylamino-propyl)-10H-phenothiazin-2-yl]-ethanone · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	70	0.32	0.76	8	empty

Compared structures

1LVJ · Structure of tar RNA complexed with a tat-tar interaction nanomolar inhibitor that was… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 1LVJ · PDBe 1LVJ

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.