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Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids

Analyse Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1LV2
Type: protein
Length: 225 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hepatocyte nuclear factor 4-gamma
UniProt: Q14541
Ligands: PLM
Pockets: 3 · best druggability 0.78

Structure

x-ray diffraction · 1 distinct chain · 64% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Hepatocyte nuclear factor 4-gamma	protein	225	64% helix, 3% strand	Q14541

Ligands and binding sites

PLM · Palmitic acid · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	466	0.78	0.86	53	PLM
2	71	0.42	0.80	12	empty
3	99	0.34	0.74	21	empty

Compared structures

1LV2 · Hepatocyte Nuclear Factor 4 is a Transcription Factor that Constitutively Binds Fatty… · the same entry in another collection · chain A against A, TM-score 1.00
Q14541 · AlphaFold monomer V2.0 prediction for hepatocyte nuclear factor 4-gamma (Q14541) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q14541
Elsewhere: RCSB PDB 1LV2 · PDBe 1LV2 · UniProt Q14541

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