Research workbench
PURIFICATION,CRYSTALLIZATION and structural analysis of cytoplastic acetoacetyl-CoA thiolase from saccharomyces cerevisiae
Analyse PURIFICATION,CRYSTALLIZATION and structural analysis of cytoplastic… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5XZ5
- Type
- protein
- Length
- 777 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Acetyl-CoA acetyltransferase
- EC
- 2.3.1.9
- UniProt
- P41338
- Pockets
- 3 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Acetyl-CoA acetyltransferase (EC 2.3.1.9) | protein | 381 | 39% helix, 22% strand | P41338 |
| B | Acetyl-CoA acetyltransferase (EC 2.3.1.9) | protein | 396 | 37% helix, 22% strand | P41338 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 308 | 0.58 | 0.77 | 29 | empty |
| 2 | 123 | 0.55 | 0.82 | 29 | empty |
| 3 | 68 | 0.30 | 0.74 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 282 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 5XZ5 · Purification,crystallization and structural analysis of cytoplastic acetoacetyl-CoA… · the same entry in another collection · chain A against A, TM-score 1.00
- P41338 · AlphaFold monomer V2.0 prediction for acetyl-CoA acetyltransferase (P41338) · a predicted model of the same protein · chain B against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P41338
- Elsewhere: RCSB PDB 5XZ5 · PDBe 5XZ5 · UniProt P41338
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