Research workbench
Crystal structure of budding yeast CDC14P (wild type) in the apo state
Analyse Crystal structure of budding yeast CDC14P (wild type) in the apo state in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5XW4
- Type
- protein
- Length
- 737 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein phosphatase CDC14
- EC
- 3.1.3.48
- UniProt
- Q00684
- Pockets
- 12 · best druggability 0.83
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein phosphatase CDC14 (EC 3.1.3.48) | protein | 368 | 42% helix, 15% strand | Q00684 |
| B | Tyrosine-protein phosphatase CDC14 (EC 3.1.3.48) | protein | 369 | 42% helix, 14% strand | Q00684 |
Pockets
12 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 177 | 0.83 | 0.97 | 40 | empty |
| 2 | 204 | 0.59 | 0.80 | 23 | empty |
| 3 | 200 | 0.56 | 0.79 | 22 | empty |
| 4 | 150 | 0.50 | 0.78 | 23 | empty |
| 5 | 128 | 0.46 | 0.78 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 1755 Ų buried · 25 hydrogen bonds · protein-protein
Compared structures
- 5XW4 · Crystal structure of budding yeast Cdc14p (wild type) in the apo state · the same entry in another collection · chain A against A, TM-score 1.00
- Q00684 · AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase CDC14 (Q00684) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q00684
- Elsewhere: RCSB PDB 5XW4 · PDBe 5XW4 · UniProt Q00684
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