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Crystal structure of a kunitz type trypsin inhibitor from cicer arietinuml

Analyse Crystal structure of a kunitz type trypsin inhibitor from cicer arietinuml in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5XOZ
Type: protein
Length: 357 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Trypsin protein inhibitor 2
UniProt: Q9M3Z7
Pockets: 3 · best druggability 0.52

Structure

x-ray diffraction · 2 distinct chains · 2% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Trypsin protein inhibitor 2	protein	178	2% helix, 42% strand	Q9M3Z7
B	Trypsin protein inhibitor 2	protein	179	2% helix, 42% strand	Q9M3Z7

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	122	0.52	0.81	26	empty
2	117	0.45	0.78	27	empty
3	60	0.30	0.75	20	empty

Interfaces

1 interface between chains.

A–B · 444 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

5XOZ · Crystal structure of a Kunitz type trypsin inhibitor from Cicer arietinumL · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9M3Z7
Elsewhere: RCSB PDB 5XOZ · PDBe 5XOZ · UniProt Q9M3Z7

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