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Crystal structure of HLA-B35 in complex with a pepetide antigen

Analyse Crystal structure of HLA-B35 in complex with a pepetide antigen in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5XOS
Type: protein
Length: 384 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: HLA class I histocompatibility antigen, B-35 alpha chain; Beta-2-microglobulin; An HIV…
UniProt: P30685, P61769
Pockets: 6 · best druggability 0.68

Structure

x-ray diffraction · 3 distinct chains · 20% helix, 41% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	HLA class I histocompatibility antigen, B-35 alpha chain	protein	276	27% helix, 39% strand	P30685
B	Beta-2-microglobulin	protein	99	0% helix, 49% strand	P61769
C	An HIV reverse transcriptase epitope	protein	9	0% helix, 0% strand	—

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	588	0.68	0.77	54	empty
2	95	0.41	0.77	14	empty
3	93	0.40	0.77	23	empty
4	61	0.38	0.79	19	empty
5	55	0.30	0.75	15	empty

Interfaces

2 interfaces between chains.

A–B · 1420 Å² buried · 24 hydrogen bonds · protein-protein
A–C · 874 Å² buried · 16 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

5XOS · Crystal structure of HLA-B35 in complex with a pepetide antigen · the same entry in another collection · chain A against A, TM-score 1.00
P61769 · AlphaFold monomer V2.0 prediction for beta-2-microglobulin (P61769) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P30685
Every structure of UniProt P61769
Elsewhere: RCSB PDB 5XOS · PDBe 5XOS · UniProt P30685 · UniProt P61769

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