Research workbench
Crystal structure of the auto-inhibited NEDD4 family E3 ligase itch
Analyse Crystal structure of the auto-inhibited NEDD4 family E3 ligase itch in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5XMC
- Type
- protein
- Length
- 409 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- E3 ubiquitin-protein ligase itchy
- EC
- 2.3.2.26
- UniProt
- Q8C863
- Pockets
- 3 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 46% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | E3 ubiquitin-protein ligase itchy (EC 2.3.2.26) | protein | 409 | 46% helix, 16% strand | Q8C863 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 847 | 0.78 | 0.81 | 88 | empty |
| 2 | 217 | 0.70 | 0.86 | 31 | empty |
| 3 | 69 | 0.29 | 0.73 | 17 | empty |
Compared structures
- 5XMC · Crystal structure of the auto-inhibited Nedd4 family E3 ligase Itch · the same entry in another collection · chain A against A, TM-score 1.00
- Q8C863 · AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase itchy (Q8C863) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8C863
- Elsewhere: RCSB PDB 5XMC · PDBe 5XMC · UniProt Q8C863
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